Quercetin is a ZINC ionophore with antiviral activity

Quercetin is a flavonoid found in capers, peppers, and onions. It has been identified as a zinc ionophore which is a compound that can transport zinc ions across a cell membrane.

Pathophysiological Basis and Rationale for Early Outpatient Treatment of SARS-CoV-2 (COVID-19) Infection

This article outlines key pathophysiological principles that relate to the patient with early infection treated at home.

Multifaceted highly targeted sequential multi-drug treatment of early ambulatory high-risk SARS-CoV-2 infection (COVID-19)

An urgent immediate pivot from single drug to targeted sequential multi-drug treatment regimens should be employed as a critical strategy to deal with the large numbers of acute COVID-19 patients with the aim of reducing the intensity and duration of symptoms and avoiding hospitalization and death. ​​

Dr. Vladimir Zelenko, Peter A. McCullough, 55 other authors

COVID-19 outpatients: early risk-stratified treatment with ZINC plus low-dose hydroxychloroquine and azithromycin: a retrospective case series study

No cardiac side effects were observed. Risk stratification-based treatment of COVID-19 outpatients as early as possible after symptom onset using triple therapy, including the combination of zinc with low-dose Hydroxychloroquine, was associated with significantly fewer hospitalizations.

Dr. Vladimir Zelenko, Roland Derwand, Martin Scholz

Does ZINC supplementation enhance the clinical efficacy of chloroquine/hydroxychloroquine to win today's battle against COVID-19?

As zinc deficiency frequently occurs in elderly patients and in those with cardiovascular disease, chronic pulmonary disease, or diabetes, we hypothesize that CQ/HCQ plus zinc supplementation may be more effective in reducing COVID-19 morbidity and mortality than CQ or HCQ in monotherapy. Therefore, CQ/HCQ in combination with zinc should be considered as additional study arm for COVID-19 clinical trials.

Dr. Vladimir Zelenko, Roland Derwand, Martin Scholz

The Potential Impact of ZINC Supplementation on COVID-19 Pathogenesis

Due to its direct antiviral properties, it can be assumed that zinc administration is beneficial for most of the population, especially those with suboptimal zinc status.

Dr. Vladimir Zelenko, Roland Derwand, Martin Scholz

Quercetin and Vitamin C: An Experimental, Synergistic Therapy for the Prevention and Treatment of SARS-CoV-2 Related Disease (COVID-19)

The use of Vitamin C and Quercetin both for prophylaxis in high-risk populations and for the treatment of COVID-19 patients as an adjunct is promising.

Dr. Vladimir Zelenko, Roland Derwand, Martin Scholz

ZINC ionophore Activity of Quercetin and Epigallocatechin-gallate (EGCG): From Hepa 1-6 Cells to a Liposome Model

Dietary plant polyphenols such as the flavonoids Quercetin (QCT) and Epigallocatechin-gallate (EGCG) act as antioxidants and as signaling molecules. Remarkably, the activities of numerous enzymes that are targeted by polyphenols are dependent on Zinc.

HCQ is effective for COVID-19 when used early: meta analysis of 185 studies

HCQ is effective for COVID-19. The probability that an ineffective treatment generated results as positive as the 185 studies to date is estimated to be 1 in 19 quadrillion. Early treatment is most successful, with 100% of studies reporting a positive effect and an estimated reduction of 65% in the effect measured (death, hospitalization, etc.) using a random effects meta-analysis.

C19study.com update: Now 118 international studies (71 peer reviewed) show positive hydroxychloroquine treatment outcomes

Comprehensive Data Base of HCQ studies.

Ivermectin is effective for COVID-19: meta analysis of 26 studies

Ivermectin is effective for COVID-19. 100% of studies report positive effects. The probability that an ineffective treatment generated results as positive as the 26 studies to date is estimated to be 1 in 67 million. Early treatment is most successful, with an estimated reduction of 87% in the effect measured using a random effects meta-analysis.

Vitamin D is effective for COVID-19: meta analysis of 35 studies

Vitamin D is effective for COVID-19. Random effects meta-analysis of the 11 treatment studies to date shows an estimated reduction of 75% in the effect measured. Sufficiency studies show a strong association between vitamin D sufficiency and outcomes. Meta-analysis of the 24 sufficiency studies shows an estimated reduction of 58%.